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BMC cancer 18, 12301239

Clinical Category Guidance & Safety Mandates Thyroid History Warning Strictly contraindicated if you or any family members have a history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Menasia syndrome type 2 (MEN 2)

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These safety concerns may become a bigger part of legal evaluations as the use of these drugs expands

Analyses addressing this estimand used data from all randomized participants from the on-treatment period (receipt of any dose of treatment within the previous 2 weeks [49 days for safety-related analyses]) until first discontinuation or rescue intervention initiation