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Derek Lowe, writing on science.org, summarized the conundrum eloquently

These drugs provide fast results for patients with type 2 diabetes, obesity and other conditions

Mitochondrial stress responses in cellular model NCI-H716 cells (CCL-251

This is coupled with a reduced oxidative stress, and these effects are beyond the glucose-lowering effects of these drugs

Not much is known about their side effects in older people

These innovations aim to offer more potent and durable clinical outcomes, improve patient responsiveness and address the growing need for advanced therapies within the global obesity landscape
