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Objective This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework

Potential neural mechanisms for effects of GLP-1RAs on nicotine reward are reviewed, and priorities for future clinical and translational studies are discussed

GLP-1 medications like semaglutide are injected once weekly, not daily