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The scope and impact is really just at a scale that we havent seen before. He cited a 2024 KPMG study estimating that caloric intake from GLP-1 users dropped 21% and monthly grocery spend fell 31%

Without the entry of the Cl counter ion, a large electrical gradient would develop from the accumulation of H + ions, halting further H + pumping and preventing acidification [59,61]

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doi: 10.4093/dmj.2023.0310

A meta-analysis of over 80,000 patients reported 16: 16% reduction in kidney failure risk 18% reduction in worsening kidney function These benefits are thought to be largely driven by improvements in: Blood sugar control Blood pressure Body weight and inflammation Fertility and Reproductive Function GLP-1 therapies have also been linked to improvements in fertility outcomes, particularly in individuals with obesity or insulin resistance

Unlike phentermine (which increases norepinephrine in the brain) or GLP-1 medications like Wegovy and Zepbound (which mimic gut hormones to reduce hunger), orlistat does not cross the blood-brain barrier and does not suppress appetite