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Administration of intravenous GLP-1 (7-36) amide to patients undergoing cardiac surgery significantly reduced their plasma glucose levels intraoperatively and may represent a novel therapeutic strategy to prevent perioperative hyperglycemia

Study Billon 2024 ob/ob mice Duration 12 days Dose & Route 50 mg/kg IP twice daily Outcome (Mouse) Improved metabolic markers in the ob/ob model

Human studies using GLP-1R agonists have provided the best support for the dependence of GLP-1R activity on glucose concentrations

TGF-1 + IL-1 promotes NLRP3 inflammasome activation, glycolysis and histone lactylation in lung fibroblasts Since fibroblasts play a central role in pulmonary fibrosis, primary mouse lung fibroblasts were isolated and cultured for further experiments

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Clinical trials found an average weight loss of 17.5% after 24 weeks, increasing to 24.2% after 48 weeks