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And we deliberately chose exenatide and lixisenatide because they have been used very successfully in the clinic and have a long safety record. Incorporating these GLP-1 therapies into the genome of lettuce also bypasses synthesis challenges faced by oral formulations, such as the need to adjust the stomach acid pH to be less acidic to prevent degradation, he explains

Now, if we took a GLP-1, we would get that signal loud and clear and also reduce our appetite

The starting dose is 0.6 mg daily and titrates up to a maximum daily dose of 1.8 mg daily

Importantly, GLP-1 loses its inhibitory effect on glucagon secretion when blood glucose levels fall, allowing an appropriate glucagon response to hypoglycaemia

Although a high dose of semaglutide reduces alcohol intake in male rats (Marty et al., 2020), additional preclinical studies are needed to explore the effects of semaglutide on alcohol drinking in various preclinical models of AUD in rats of both sexes