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Tirzepatide is not and should not be considered a disease-modifying antirheumatic drug

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Furthermore, pre-synaptic and post-synaptic proteins, synaptophysin and PSD-95, which reflect synaptic disruption [122], were upregulated, neuronal excitability normalized, and intracellular calcium, a key regulator in metabolic dysfunction and progressive neuronal loss [123], was modulated [121]

17 Why the dual agonist outperforms the single one is still being resolved

Cortisol dominates the second
doi: 10.1007/s00125-022-05732-3
