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n paralel cu formele injectabile, PIONEER 6 (Husain i colab., 2019) a investigat Semaglutide la pacieni cu diabet de tip 2 i risc crescut, iar rezultatele arat c, n ceea ce privete evenimentele cardiovasculare majore, profilul su nu este inferior placebo (non-inferiority), ceea ce reprezint un pas important n evaluarea siguranei variantei orale n context cardiovascular