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The creatures glucose-regulating system must therefore possess remarkable flexibility and, crucially, the hormonal signals that trigger insulin release must be extraordinarily durable

Given the demand for these agents, there have been several supply shortages leading to access issues and an increase in cost

Gastrointestinal-related adverse events typically emerged early in the treatment period and generally diminished upon dose adjustment

Because it provides a constant level of insulin regardless of blood sugar status, blood glucose can drop dangerously low if a patient skips meals, exercises vigorously, or takes too much insulin

Low incidence of anti-drug antibodies in patients with type 2 diabetes treated with once-weekly glucagon-like peptide-1 receptor agonist dulaglutide

Chen C, Zheng H, Xu J, Shi X, Li F, Wang X