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Description

Results Reducing dose frequency does not commensurately reduce weight loss

GLP-1 receptor agonists are a novel class of pharmacological agents for obesity and T2D

Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed conformation of the extracellular domain.

Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit

Learn how they differ from prescription medications, review the clinical evidence, understand safety considerations, and explore NHS-approved weight management treatments backed by NICE guidance.