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Improvement of metabolic control and quality of life

GLP-1 has many beneficial effects on the control of blood glucose levels including stimulation of insulin secretion and inhibition of glucagon secretion, expansion of the beta-cell mass by stimulating beta-cell proliferation and differentiation and inhibiting beta-cell apoptosis, delay of gastric emptying, and reduction of food intake [46]

These effects seem to be mediated by GLUT4, which triggers PI3K/PKB, and glucose, which inhibits the LKB1/AMPK pathway

Elaine Yu, who directs the Bone Density Center at Massachusetts General Hospital in Boston, didnt find this particular difference very clinically impactful, for the reason that the condition is often coded for incorrectly and is likely underdiagnosed in both groups

v3.71.0 They don't care about patients health, but money It is ridiculous that they prescribed Wegovy 1.0mg for me even though I was previously taking Mounjaro 2.5mg

However, these drugs can be expensive for the patient, even with qualifying rebates and discounts by the manufacturer, and adding them to a plan formulary may carry similar risk