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Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production (Jiang et al., 2024)
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Here are the most reliable indicators that semaglutide ended up in muscle rather than fat
In general, tirzepatide results in greater weight loss compared to semaglutide
These effects have led to the development of GLP-1 agonists as a treatment for type 2 diabetes
Second, it helps predict glucose improvements since weight loss correlates strongly with improved insulin sensitivity
