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This warning applies if someone has a personal or family history of medullary thyroid carcinoma or MEN-2

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Studies incorporating formal measures of body compositiondistinguishing between fat mass and muscle masscould provide additional insights, as weight loss may result from reductions in both, and the degree of each may differ between individuals and between drivers of weight loss

These include dose optimization (if you are not yet at the maximum therapeutic dose), dietary modifications (recalculating caloric needs for your current weight), increasing physical activity (particularly resistance training to preserve metabolic rate), and addressing sleep and stress factors that influence cortisol and insulin

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