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69% have been using the medication for fewer than two years and 53% expect to discontinue use in less than two more years 77% who had discontinued a GLP-1 medication said they were satisfied with the weight loss they experienced, but 90% were on the drug for less than one year Primary barriers to continued use: 76% note side effects

GLP-1 therapy can also affect gut health

Patients with both type 2 diabetes and obesity may find the drug especially helpful, as it targets two significant health challenges simultaneously

Therefore, effective contraception is essential while using GLP-1 receptor agonists, and they should be discontinued appropriately before attempting conception

Mounjaro may be more effective than Ozempic for managing blood sugar and weight loss, with up to a 2.30% reduction in HbA1c and up to 20% body weight loss, compared to 1.86% and 10% with Ozempic

NICE guidance on obesity management (CG189 and related technology appraisals) emphasises the importance of regular monitoring and individualised care principles that apply equally to emerging treatments such as retatrutide