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Similarly, the STEP UP Obesity trial revealed that about 33% of patients on the 7.2 mg dose lost 25% or more of their starting weight, while only 15% of those on the lower dose achieved the same level of weight loss

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Previous research has demonstrated increased amino acid catabolism in skeletal muscle with low glycogen content, and further research is needed to determine if skeletal muscle loss in patients taking GLP-1RA can be mitigated through synergistic pharmaceutical or dietary interventions to maximize skeletal muscle glycogen content [165]

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With a half-life of roughly six days, each weekly injection builds upon residual levels from previous doses until steady state is achieved around weeks four to five

Data beyond 1 year represent only the subset of patients who maintained therapy and follow-up to that time point (Fig