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Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis

Day 1-3 might feel deceptively normalkind of like the calm before the storm

It has even been indicated that all GLP-1 released by L-cells is inactivated before it reaches the pancreas and that GLP-1 mediated insulin release is induced by local paracrine actions in the islets during the postprandial period, and there is emerging evidence that this is the case, which would mean that GLP-1 released by L-cells only acts on its receptor (GLP-1R) expressed on nerve terminals of neighboring vagal afferents, conveying signalling to the solitary nucleus of the hindbrain to promote satiety, delay gastric emptying and suppress hepatic glucose production

N Engl J Med 2018;379:110717

For male fertility, research is even more sparse

Shotsy raised its premium plan from $29.99 to $49.99 per year after securing venture funding, so some tools now sit behind a steeper paywall