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The lower esophageal sphincter (LES) is a muscular valve located at the top of the stomach that opens to let food enter, and then closes to keep the digestive acids and food in the stomach

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Because the incidence of AEs was greatest during dose escalation, the disparity in total years of exposure between the two trials could potentially dilute the reported rate of AEs in PIONEER 3 compared with PIONEER 12

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Without a functioning thyroid, weight gain often stems from hormonal imbalance or insufficient replacement, and correcting the replacement dose sometimes resolves weight gain before Semaglutide is even needed

Some patients may also experience abdominal pain or discomfort