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The faster gastric emptying on tirzepatide reduces the "food sitting in stomach" sensation

Mechanism: The mechanism of EC is unknown but has been shown to involve such things as the inhibition or delay of ovulation, alteration in endometrial receptivity for implantation, interference with the ability of the corpus luteum to maintain pregnancy, production of cervical mucus that prevents sperm penetration, and changes in tubular transport of sperm, egg, or embryo

GLP-1 receptor agonists such as semaglutide work by slowing gastric emptying and signaling fullness to the brainbut alcohol can interfere with these mechanisms

The hormone also slows gastric emptying, prolonging the time food remains in the stomach and moderating postprandial glucose excursions

Most side effects lessen with gradual dose titration

doi: 10.1002/chem.201805038