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Description
Anecdotal reports suggest UTI risk is highest during the initial weeks and during dose increases, which aligns with when GI side effects (and therefore dehydration risk) are most pronounced

In these cases, it can be challenging to determine whether semaglutide is directly responsible for the night sweats or if it is a contributing factor

Avoiding alcohol and other sedatives is essential, as they can worsen drowsiness

Even though it is rare, GLP1 drugs may increase the risk of pancreatitis and gallstones, especially in those with a history of these conditions

This might include temporary use of short-acting insulin, adjustment of other diabetes medications, or increased glucose monitoring to maintain blood glucose targets of 80-180 mg/dL per American Diabetes Association guidelines

Unlike sulfonylureas, which stimulate insulin secretion independently of blood glucose and can lead to hypoglycemia, GLP-1RAs improve glycemic control in a glucose-dependent manner, thereby minimizing the risk of hypoglycemia
