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Due to the long half-life of elimination of about one week, weekly dosing results in drug accumulation, i.e., the plasma concentrations at steady state are higher than the concentrations after the first dose

However, Wegovy is FDA approved for weight loss and type 2 diabetes, while Ozempic is only approved for the latter

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10.1111/bcp.15757 7 MllerT

doi: 10.1186/s12933-025-02607-w 14

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