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They wrote in Annals of Internal Medicine that first-line treatments for obesity and overweight include physical activity and nutrition, but the new guidance addresses additional management using pharmacologic treatments when lifestyle modifications alone do not result in optimal weight loss or weight maintenance for a person. ACPs recommendations also come as other professional medical societies and organizations, including WHO, The Obesity Society and Obesity Medicine Association, have announced their support of medications like GLP-1 receptor agonists for obesity

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PlexusDx protocols can be customized and your healthcare provider may recommend switching to oral semaglutide or exploring alternative GLP-1 compounds if injection-related cold sensitivity is problematic

From these, we included those articles that employed synthetic methods, in vivo study, or discussion of tirzepatide clinical trials