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Using a conservative effect size of 0.2, for an error of 5% and a power of 80%, a minimum of 199 subjects would be required

These mental health challenges can persist even after ceasing use of the drug, requiring long-term treatment and support

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The only study currently available that collected questionnaire data on smoking and e-cigarettes in pregnant women 10 suggests that the use of e-cigarettes during pregnancy in 248 women causes fetal growth restriction, which in turn is a proposed risk factor for impaired lung function development and respiratory hyper-reactivity 11,12,13

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