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Transl Cancer Res 2020

[58] The distinction between nicotine and tobacco smoke is central to discussions of smoking-related diseases

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If smokers inhaled a vapor containing nicotine, flavorings and other additives rather than the multitude of cancer-causing chemicals in tobacco smoke, there might be some benefit

Over time, this constant stress on the cardiovascular system can lead to hypertension (high blood pressure), which is a major risk factor for heart disease
September 2017: A Nicotine-Focused Framework for Public Health, by FDA Commissioner Scott Gottlieb and CTP Director Mitchell Zeller in the New England Journal of Medicine
