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PA then diffuses back into the bacilli, where it accumulates and exerts multiple effects against Mtb, including inhibition of fatty acid synthase, disruption of membrane potential, and interference with energy production by interacting with ribosomal protein S1 to inhibit trans-translation (Boshoff, Mizrahi, and Barry, 2002

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The act was phased in over three years

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Learn about thrombocytopenia symptoms and treatment.