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DNA damage can rapidly increase the levels of P53 and stabilize it [6]
Epigenetic dysregulation that leads to inappropriate gene expression or silence has been shown to play a significant role in the CS-related diseases
Feng et al
p53 and NF-B Coregulate Proinflammatory Gene Responses in Human Macrophages
Once phosphorylated, c-Jun and c-Fos can dimerize to form the AP-1 transcription factor, which translocates to the nucleus, where it binds to specific DNA sequences known as AP-1 binding sites
Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P
