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It did.

Discussion This study explored the prevalence of DSM-5 TUD in tobacco users diagnosed with lung cancer and comprehensively analyzed the tobacco use characteristics

People who are smokers, they should at least experience stop smoking for a day and them expand it for some time

Smoking has widespread negative effects on the digestive system, contributing to chronic conditions and raising the risk of gastrointestinal cancers

What this shows is that genetic studies can tell us as much about environmental influences, as about underlying biology