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Alfonsi is a "60 Minutes" investigative correspondent

Cotinine upregulates the 7nAChRs and this activity is neuroprotective to glial cells (Iarkov et al., 2021)

Evidence-based cessation resources include: FDA-approved nicotine replacement therapy (patches, gum, lozenges) Prescription medications (varenicline, bupropion) Behavioral counseling and support programs Quitlines and online cessation tools Healthcare provider guidance The WHO Framework Convention on Tobacco Control, adopted by 183 countries, provides comprehensive tobacco control measures including cessation support

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Preliminary studies show that organic compounds (such as nicotine, pesticide residues and metal) seep from cigarette butts into aquatic ecosystems , becoming acutely toxic to fish and microorganisms

Reddy KS, Gupta PC