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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

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With long-term exposure to nicotine intake neuroadaptation (tolerance) develops, the existing nAChRs become less sensitive (desensitization/inactivation), which is accompanied by nicotine-induced upregulation of the receptor 18,21

Smoking remains the leading cause of preventable death in the United Kingdom, accounting for over 77,000 deaths an estimated 2.5 billion in health care costs each year in England alone

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On sociology: Numbers, narratives, and the integration of research and theory