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This pro-inflammatory response of epithelial cells to CSE is achieved by altering a variety of signaling pathways involved in cellular activation, primarily protein kinase C (PKC), mitogen-actived protein kinase (MAPK), NFB and activatory protein-1 (AP-1) pathways [102,134,135,136]

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[2] Cigarette girls were a common sight in restaurants, clubs, bars, airports, and casinos in the 1930s and 1940s in the United States

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