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As a result, there is reduced concentration of these antipsychotics in medicated SZ smokers, which predictably leads to a reduction in side effects, motivating further use (113) (supporting the self-medication hypothesis)

Pipe smokers often keep a small jar on their desk or table so they can grab a bowls worth of leaf without exposing the entire supply

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A basic hypothesis is that free radicals cause oxidative damage to macromolecules such as lipids, proteins, and DNA