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In future studies, it would be of considerable interest to understand how sustained smoking behaviour, driven initially by hedonic experience may further develop into dependence (i.e., psychological or physical craving for nicotine following withdraw), where habit-inducing regions such as the insula and striatum might eventually become involved 55,56

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For nicotine products, the number of cigarettes smoked or the amount of vapor inhaled has a much clearer connection to any harm caused by this consumption than the retail sales price of the products