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Oxidative stress attacks your testosterone factories Leydig cells in the testes produce most of your testosterone, and cigarette smoke bathes those cells in heavy metals, like cadmium and lead

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Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence