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The availability of a phenotypic marker of CYP2A6 activity is important because there is wide variability in nicotine clearance among people with wild-type CYP2A6 genes and only a small proportion of the genetic variability in nicotine clearance can be explained by known CYP2A6 gene variants, at least in whites (Swan et al

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But when you smoke again, even one cigarette shocks your system