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From this weakness it proceeds that many in this kingdom have had such a continual use of taking this unsavory smoke as now they are not able to forbear the same, no more than an old drunkard can abide to be long sober without falling into an incurable weakness and evil constitution

A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N 7 -(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring