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Rangel notes, Thats why these products and others like it come with the FDA warning label that they contain nicotine and that they are highly addictive. Rangel clarifies that the FDA authorizes the marketing of these products, but it does not endorse their use

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Nicotine and the many substances found in cigarette smoke promote the narrowing of blood vessels, inflammation and changes in blood circulation
Journal of the American College of Cardiology, 73 (21), 27222737
They're silent for a moment

Luckily, all of these harms from smoking, and more, are preventable