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Data synthesis and meta-analysis From the nine studies included in the final meta-analysis, the following data were extracted where available: country of study, investigator name and year of publication, study design, study size, and reported adjusted OR with 95% confidence interval (CI) and p -value

The processing methods origin is attributed to Sir Thomas Cavendish, who, while on an expedition to Virginia in 1585, discovered that dipping tobacco leaves into sugar produced a milder smoke

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