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During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (seePRECAUTIONS,Renal Effects), as well as to assure diuretic efficacy

This subgroup represents the largest subgroup with non-significant Q-statistic

More specifically, several studies have shown that one year after stopping smoking, the average weight gain was between 2.5 kg and 5 kg, and that it occurred especially during the first two years after stopping and then lessens

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However, some small differences depend on cigarette length, filter type, and packing style