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We found that small amounts of deuterium-labeled nornicotine are excreted in the urine of smokers administered deuterium-labeled nicotine (Jacob and Benowitz 1991)

[7] Nicotine is a parasympathomimetic stimulant [8] that binds to and activates nicotinic acetylcholine receptors in the brain, [9] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate and endorphins

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Demand for tobacco leaf is a derived demand (see Box 1)

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Studies show that adults who are being treated for SUD are more likely to remain in remission if they also quit smoking