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Similarly, mice with p53 mutations that impair the transcriptional activation of p21 , Puma and Noxa , but retain the ability to induce the transcription of certain other p53 target genes, also do not develop tumours spontaneously [38]

HCC has a strong male preponderance, with a male-to-female ratio estimated to be 22.5:1 3

Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer

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14 : 393400 McCoy G, Wynder E

Survival in operable non-small-cell lung cancer: role of p53 mutations, tobacco smoking and asbestos exposure