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So, by silencing the circuit, we were able to demonstrate for certain that this was a very important neural encoder of the behavioral aspect of high-dose nicotine. The only drug designed to help with nicotine cessation, varenicline, could work by increasing aversion via the alpha-7 receptor and lessening desensitization of the alpha-4/beta-2 receptor, she said, but its precise mechanism of action is currently unknown
Bastard JP, Pieroni L
Its great fun, not just because its an extremely complex topic, but also because the best approach for many people is also the simplest and cheapest: weatherizing their homes
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