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A very recent study seems to find out a link between LGR-5 and HCC initiation: LGR-5 can induce p53 degradation and disrupt its stabilization by interfering with programmed cell death protein 5 (PDCD5) nuclear translocation, which could contribute to the long life of abnormal proliferative hepatocytes 53
doi: 10.1038/cddis.2011.19 88 LiMYuMLiuCZhuHHeXPengSet al

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