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Monoamine oxidase inhibitors (MAOIs) combine with nicotine to produce a reinforcing effect in the brain that makes users want nicotine more often

doi:10.1093/ntr/ntab047

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Smoking is the most common cause of COPD, but long-term exposure to air pollution or chemicals can also play a role

Handicapped as he was, this second, more debilitating restriction didn't prevent the actor from delivering some of his finest screen work