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Am J Respir Crit Care Med 2002;166:12359.ArticlePubMed 4

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Reasons highlighted for the shortage included manufacturing issues, supply chain disruptions, increased demand, and regulatory challenges, with the DEA noting that manufacturers did not reach maximal production, leading to a shortage of 1 billion dosages

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There is also a huge population among women who are exposed to the risk factors regarding traditional cigarettes, as well as smokeless tobacco and electronic nicotine delivery systems, as these products are mistakenly perceived to be harmless