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These products must be subject to the same advertising bans, indoor-use restrictions, and taxation policies as combustible tobacco to prevent another generation from lifelong CV harm

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How Carcinogens in Cigarette Smoke Cause Lung Cancer The carcinogens in cigarette smoke that are inhaled can be metabolically activated (most notably by cytochrome P450 enzymes in the liver) to intermediate compounds that covalently or (sometimes) directly bind to DNA

We further excluded women with missing data on maternal cigarette smoking ( n = 67,209), birth congenital anomalies ( n = 20,693), or on covariates (maternal demographics, maternal pregnancy risk factors, gestational age at delivery, and pregnancy history or prenatal care

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