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PIP3 acts in turn as a docking site for two kinases, phosphoinositide-dependent kinase 1 (PDK1) and Akt, and the subsequent phosphorylation of Akt at serine 308 by PDK1, leading to Akt activation

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Moreover, a higher amount of apoptosis inducing factors were found in mice liver, indicating that ferroptosis plays a key role in NASH-associated cell death [90]

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Researchers also employ the modified version of DMEM for a wide array of research applications, such as drug discovery, tissue engineering, and the study of cell signaling pathways

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