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10.1021/jm00036a016 J

This review differentiates between low-dose methotrexate used in autoimmune diseases and high-dose methotrexate used in oncology, emphasizing mechanistic differences in hepatotoxicity pathways, integrating MASLD-related risk factors, and summarizing current non-invasive diagnostic strategies

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For example, as a mechanism driving the pathogenesis of PH, the systemic inflammatory response is related to the microbiome