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Passaia, G., Queval, G., Bai, J., Margis-Pinheiro, M
As limited options are available to effectively treat CIPN once it is established [34], a pharmacological approach, such as the inhibition of C5aR1, able to prevent CIPN from developing, can open an entirely new scenario for the prevention of this frequent and severely impairing side effect

Nevertheless, most research studies recommend hydroquinone to treat melasma

Historically, in many parts of the world, lighter skin has been associated with certain standards of beauty or social standing, driving demand for treatments like glutathione skin lightening IV therapy

This hypothesis is largely based on studies showing that exogenously added ROS induce inflammatory cytokines, while addition of antioxidants, including the main thiol antioxidant, glutathione (GSH), inhibits it

Jain N, Keating MJ, Thompson PA, Ferrajoli A, Burger JA, Borthakur G , Takahashi K, Estrov ZE, Fowler NH, Kadia TM, Konopleva MY, Alvarado Y, Yilmaz M, DiNardo CD, Bose P, Ohanian M, Pemmaraju N, Jabbour EJ, Sasaki K, Kanagal-Shamanna R, Patel K, Jorgensen JL, Garg N, Wang X, Sondermann K, Cruz N, Wei C, Ayala A, Plunkett W, Kantarjian H, Gandhi V, Wierda WG
