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Recent evidence supports a move away from dopamine agonists (pramipexole, ropinirole) as first-line agents due to the significant risk of augmentation, as well as impulse control disorders

The two compounds work through different but highly complementary pathways

K.ReddanD

Generalized sensorimotor polyneuropathies were found in the NCS

This phenomenon is thought to operate particularly in those neuronal systems using glutamate as a transmitter, such as the cells in the hippocampal areas mentioned previously

So I wanted to kind of have a background to really explain how the process works
