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The elevation of extracellular glu levels suppresses system Xc-, leading to the initiation of ferroptosis ( 3.1.1 System Xc- System Xc-is consisted of SLC7A11 (catalytic subunit) and solute carrier family 3 member 2 (SLC3A2, regulatory subunit) (Sato et al., 1999)

10.1136/thoraxjnl-2017-210106 87

Lancet 390 , 27692778 (2017)

Webb WR, Rao P, Carruthers JDA, et al

For each rate study, 50 M of reduced protein was incubated in a reaction mixture containing 1 mM DCP-Bio1, 25 mM potassium phosphate (pH 7.0), 100 M DTPA (an aggressive chelating reagent) with one (AhpC) or two (papain) equivalents of H 2 O 2 (fRMsr was oxidized with a 100-fold excess of methionine sulfoxide)

Hills Prescription Diet y/d is formulated to limit iodine intake, thereby reducing thyroid hormone synthesis