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NAFLD is estimated to affect 25% of the population worldwide [81] but, to date, there are no specific therapies available for the treatment [82], although some pharmacological strategies used for related disorder (e.g., diabetes) are also recommended for the treatment of NAFLD patients [79]

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doi: 10.1007/s11101-025-10123-8 68 RakholiyaKDKaneriaMJShaikhAMWandhekarSSChandaSV

Calcium depletion also increases the activity of myosin light chain phosphatase

The activation of both types of IL-4 receptors leads to the phosphorylation of Janus kinase (JAK) 1, Jak2, and Tyk2, activating STAT-6 transcription factors and leading to the gene expression of target inflammatory mediators